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Seller-Pérez, Gemma; Herrera-Gutiérrez, Manuel E.; Aragón-González, Cesar; Granados, Maria M.; Dominguez, Juan M.; Navarrete, Rocío; Quesada-García, Guillermo; Morgaz, Juán; Gómez-Villamandos, Rafael

Bladder Mucosal CO2Compared with Gastric Mucosal CO2as a Marker for Low Perfusion States in Septic Shock

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  • Media type: E-Article
  • Title: Bladder Mucosal CO2Compared with Gastric Mucosal CO2as a Marker for Low Perfusion States in Septic Shock
  • Contributor: Seller-Pérez, Gemma; Herrera-Gutiérrez, Manuel E.; Aragón-González, Cesar; Granados, Maria M.; Dominguez, Juan M.; Navarrete, Rocío; Quesada-García, Guillermo; Morgaz, Juán; Gómez-Villamandos, Rafael
  • imprint: Hindawi Limited, 2012
  • Published in: The Scientific World Journal
  • Language: English
  • DOI: 10.1100/2012/360378
  • ISSN: 1537-744X
  • Keywords: General Environmental Science ; General Biochemistry, Genetics and Molecular Biology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>Recent reports indicate the possible role of bladder CO<jats:sub>2</jats:sub>as a marker of low perfusion states. To test this hypothesis, shock was induced in six beagle dogs with 1 mg/kg of<jats:italic>E. coli</jats:italic>lipopolysaccharide, gastric CO<jats:sub>2</jats:sub>(CO<jats:sub>2</jats:sub>-G) was measured with a continuous monitor, and a pulmonary catheter was inserted in the bladder to measure CO<jats:sub>2</jats:sub>(CO<jats:sub>2</jats:sub>-B). Levels of CO<jats:sub>2</jats:sub>-B were found to be lower than those of CO<jats:sub>2</jats:sub>-G, with a mean difference of 36.8 mmHg (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mn fontstyle="italic">0.001</mml:mn></mml:math>), and correlation between both measurements was poor (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>0.16</mml:mn></mml:math>). Even when the correlation between CO<jats:sub>2</jats:sub>-G and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>Δ</mml:mo></mml:math>CO<jats:sub>2</jats:sub>-G was narrow (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>0.86</mml:mn></mml:math>), this was not the case for the relationship between CO<jats:sub>2</jats:sub>-B and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>Δ</mml:mo></mml:math>CO<jats:sub>2</jats:sub>-B (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>0.29</mml:mn></mml:math>). Finally, the correlation between CO<jats:sub>2</jats:sub>-G and base deficit was good (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>0.45</mml:mn></mml:math>), which was not the case with the CO<jats:sub>2</jats:sub>-B correlation (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow><mml:mi>r</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>0.03</mml:mn></mml:math>). In our experience, bladder CO<jats:sub>2</jats:sub>does not correlate to hemodynamic parameters and does not substitute gastric CO<jats:sub>2</jats:sub>for detection of low perfusion states.</jats:p>
  • Access State: Open Access