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Media type:
E-Article
Title:
Protein networks in disease
Contributor:
Ideker, Trey;
Sharan, Roded
Published:
Cold Spring Harbor Laboratory, 2008
Published in:
Genome Research, 18 (2008) 4, Seite 644-652
Language:
English
DOI:
10.1101/gr.071852.107
ISSN:
1088-9051
Origination:
Footnote:
Description:
During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage.