• Media type: E-Article
  • Title: Perirhinal Cortex Lesions Impair Context Aversion Learning
  • Contributor: Howse, Dana J.; Squires, Amanda S.; Martin, Gerard M.; Skinner, Darlene M.
  • imprint: Cold Spring Harbor Laboratory, 2003
  • Published in: Learning & Memory
  • Language: English
  • DOI: 10.1101/lm.57803
  • ISSN: 1072-0502; 1549-5485
  • Keywords: Cellular and Molecular Neuroscience ; Cognitive Neuroscience ; Neuropsychology and Physiological Psychology
  • Origination:
  • Footnote:
  • Description: <jats:p>Rats with perirhinal cortex lesions were compared with sham controls on a conditional discrimination in which saccharin was paired with LiCl in context 1, but paired with saline in context 2. Perirhinal-lesioned rats were slightly slower to acquire the discrimination but reached control levels by the end of acquisition. Both groups showed transfer to familiar tap water, consuming less in context 1 than in context 2. Unlike sham rats, perirhinal rats failed to show an aversion to context 1 on a place choice test. These data provide neuroanatomical support for the postulated difference between Pavlovian conditioning and conditional learning.</jats:p>
  • Access State: Open Access