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Lambert, M.; Schöttle, D.; Ruppelt, F.; Rohenkohl, A.; Sengutta, M.; Luedecke, D.; Nawara, L. A.; Galling, B.; Falk, A.‐L.; Wittmann, L.; Niehaus, V.; Sarikaya, G.; Rietschel, L.; Gagern, C.; Schulte‐Markwort, M.; Unger, H.‐P.; Ott, S.; Romer, G.; Daubmann, A.; Wegscheider, K.; Correll, C. U.; Schimmelmann, B. G.; Wiedemann, K.; Bock, T.; [...]

Early detection and integrated care for adolescents and young adults with psychotic disorders: the ACCESS III study

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  • Media type: E-Article
  • Title: Early detection and integrated care for adolescents and young adults with psychotic disorders: the ACCESS III study
  • Contributor: Lambert, M.; Schöttle, D.; Ruppelt, F.; Rohenkohl, A.; Sengutta, M.; Luedecke, D.; Nawara, L. A.; Galling, B.; Falk, A.‐L.; Wittmann, L.; Niehaus, V.; Sarikaya, G.; Rietschel, L.; Gagern, C.; Schulte‐Markwort, M.; Unger, H.‐P.; Ott, S.; Romer, G.; Daubmann, A.; Wegscheider, K.; Correll, C. U.; Schimmelmann, B. G.; Wiedemann, K.; Bock, T.; [...]
  • Published: Wiley, 2017
  • Published in: Acta Psychiatrica Scandinavica, 136 (2017) 2, Seite 188-200
  • Language: English
  • DOI: 10.1111/acps.12762
  • ISSN: 0001-690X; 1600-0447
  • Origination:
  • Footnote:
  • Description: ObjectiveThe objective of the study was to investigate whether a combined intervention composed of early detection plus integrated care (EDIC) enhances outcomes in patients with early psychosis compared to standard care (SC).MethodsACCESS III is a prospective non‐randomized historical control design 1‐year study examining the efficacy of EDIC (n = 120) vs. SC (n = 105) in patients aged 12–29 years. Primary outcome was the rate of ≥6 months combined symptomatic and functional remission. Additional outcomes comprised the reduction of DUP and course of psychopathology, functioning, quality of life, and satisfaction with care.ResultsIn observed cases, 48.9% in the EDIC and 15.2% in the SC group reached the primary endpoint. Remission was predicted by EDIC (OR = 6.8, CI: 3.15–14.53, P < 0.001); younger age predicted non‐remission (OR = 1.1, CI: 1.01–1.19, P = 0.038). Linear regressions indicated a reduction of DUP in EDIC (P < 0.001), but not in SC (P = 0.41). MMRMs showed significantly larger improvements in PANSS positive (P < 0.001) and GAF (P < 0.01) scores in EDIC vs. SC, and in EDIC over time in CGI‐Severity (P < 0.001) and numerically in Q‐LES‐Q‐18 (P = 0.052).ConclusionsEDIC lead to significantly higher proportions of patients achieving combined remission. Moderating variables included a reduction of DUP and EDIC, offering psychotherapeutic interventions.