Dickerson, F.;
Origoni, A.;
Schroeder, J.;
Adamos, M.;
Katsafanas, E.;
Khushalani, S.;
Savage, C. L. G.;
Schweinfurth, L. A. B.;
Stallings, C.;
Sweeney, K.;
Yolken, R.
Natural cause mortality in persons with serious mental illness
You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Natural cause mortality in persons with serious mental illness
Contributor:
Dickerson, F.;
Origoni, A.;
Schroeder, J.;
Adamos, M.;
Katsafanas, E.;
Khushalani, S.;
Savage, C. L. G.;
Schweinfurth, L. A. B.;
Stallings, C.;
Sweeney, K.;
Yolken, R.
Description:
<jats:sec><jats:title>Objective</jats:title><jats:p>To identify the determinants of natural cause mortality in a cohort of individuals with serious mental illness assessed prospectively.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Persons with schizophrenia (<jats:italic>n</jats:italic> = 789) and bipolar disorder (<jats:italic>n</jats:italic> = 498), mean age of 38 (s.d. 12.6) years, underwent an in‐person clinical assessment. They also had a blood sample drawn from which infectious disease markers were measured. Mortality was subsequently determined utilizing data from the National Death Index following a period of up to 16.9 years.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 6.8% (87 of 1287) of persons died of natural causes. Mortality was predicted in a multivariate model by baseline cigarette smoking (RR = 6.29, 95% CI 1.41, 3.72, <jats:italic>P</jats:italic> = 0.00076); divorced or widowed status (RR = 1.90, CI 1.21, 2.99); reduced cognitive score (RR = 0.73, CI 0.61, 0.87); receipt of antidepressant medication (RR = 1.74, CI 1.12, 2.71); elevated levels of antibodies to Epstein–Barr virus (EBV) (RR = 1.29, CI 1.01, 1.66); and a genitourinary (RR = 1.82, CI 1.16, 2.86), respiratory (RR = 1.82, CI 1.16, 2.86), or cardiac (RR = 2.09, CI 1.33, 3.29) condition. There was an additive effect of smoking and both a cardiac and a respiratory condition but not elevated EBV antibody levels.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Smoking is a modifiable behaviour which is associated with mortality in this population.</jats:p></jats:sec>