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Media type:
E-Article
Title:
Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction
Contributor:
Barrós‐Loscertales, Alfonso;
Costumero, Víctor;
Rosell‐Negre, Patricia;
Fuentes‐Claramonte, Paola;
Llopis‐Llacer, Juan‐José;
Bustamante, Juan Carlos
Published:
Wiley, 2020
Published in:
Addiction Biology, 25 (2020) 4
Language:
English
DOI:
10.1111/adb.12820
ISSN:
1355-6215;
1369-1600
Origination:
Footnote:
Description:
AbstractCocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal‐directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction affected the left frontoparietal network during goal‐directed behavior in a stop‐signal task (SST) with reward contingencies by correct task performance. Twenty‐eight healthy controls (HC) and 30 abstinent cocaine‐dependent patients (ACD) performed SST with monetary reward contingencies while undergoing a functional magnetic resonance imaging scan. The results showed that the left frontoparietal network (FPN) displayed an effect of cocaine addiction depending on reward contingencies rather than inhibition accuracy; and, second, we observed a negative correlation between dependence severity and the modulation of the left FPN network by the monetary reward in ACD. These findings highlight the role of the left FPN in the motivational effects of cocaine dependence.