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Media type:
E-Article
Title:
TRP channels in the skin
Contributor:
Tóth, Balázs I;
Oláh, Attila;
Szöllősi, Attila Gábor;
Bíró, Tamás
Published:
Wiley, 2014
Published in:
British Journal of Pharmacology, 171 (2014) 10, Seite 2568-2581
Language:
English
DOI:
10.1111/bph.12569
ISSN:
0007-1188;
1476-5381
Origination:
Footnote:
Description:
<jats:sec><jats:label /><jats:p>Emerging evidence suggests that transient receptor potential (<jats:styled-content style="fixed-case">TRP</jats:styled-content>) ion channels not only act as ‘polymodal cellular sensors’ on sensory neurons but are also functionally expressed by a multitude of non‐neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous <jats:styled-content style="fixed-case">TRP</jats:styled-content> channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several <jats:styled-content style="fixed-case">TRP</jats:styled-content> channels in the development of certain skin diseases and identify future <jats:styled-content style="fixed-case">TRP</jats:styled-content> channel‐targeted therapeutic opportunities.</jats:p></jats:sec><jats:sec><jats:title>Linked Articles</jats:title><jats:p>This article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://dx.doi.org/10.1111/bph.2014.171.issue-10">http://dx.doi.org/10.1111/bph.2014.171.issue‐10</jats:ext-link></jats:p></jats:sec>