You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
Contributor:
Ohtani, Naoko;
Hara, Eiji
Published:
Wiley, 2013
Published in:
Cancer Science, 104 (2013) 5, Seite 525-530
Language:
English
DOI:
10.1111/cas.12118
ISSN:
1347-9032;
1349-7006
Origination:
Footnote:
Description:
Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli and has therefore long been considered to suppress tumorigenesis, acting as a guardian of homeostasis. However, surprisingly, emerging evidence reveals that senescent cells also promote secretion of a series of inflammatory cytokines, chemokines, growth factors and matrix remodeling factors, which alter the local tissue environment and contribute to chronic inflammation and cancer. This newly identified senescence phenotype, termed the senescence‐associated secretory phenotype (SASP) or the senescence‐messaging secretome (SMS), is induced by DNA damage that promotes the induction of cellular senescence. All of these senescence‐associated secreting factors are involved in homeostatic disorders such as cancer. Therefore, it is quite possible that accumulation of senescent cells during the aging process in vivo might contribute to age‐related increases in homeostatic disorders. In this review, current knowledge of the molecular and cellular biology of cellular senescence is introduced, focusing on its positive and negative roles in controlling tissue homeostasis in vivo.