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Media type:
E-Article
Title:
Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus
Contributor:
Al‐Qaissi, Ahmed;
Papageorgiou, Maria;
Javed, Zeeshan;
Heise, Tim;
Rigby, Alan S.;
Garrett, Andrew T.;
Hepburn, David;
Kilpatrick, Eric S.;
Atkin, Stephen L.;
Sathyapalan, Thozhukat
Published:
Wiley, 2019
Published in:
Diabetes, Obesity and Metabolism, 21 (2019) 3, Seite 569-574
Language:
English
DOI:
10.1111/dom.13555
ISSN:
1463-1326;
1462-8902
Origination:
Footnote:
Description:
ObjectiveThis study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes.Materials and methodsA three‐way, cross‐over, randomised study was performed in adults with type 1 diabetes mellitus (n = 10). The pharmacodynamics profile of a single dose of short‐acting insulin (insulin lispro) was investigated, using a controlled environmental chamber, under three environmental conditions: (a) temperature: 15°C and humidity: 10%; (b) temperature: 30°C and humidity: 10%; and (c) temperature: 30°C and humidity: 60%. A euglycaemic glucose clamp technique ensured constant blood glucose of 100 mg/dL (5.5 mmol/L). The following pharmacodynamic endpoints were calculated: maximum glucose infusion rate (GIRmax), time to GIRmax (tGIRmax), total area under the curve (AUC) for GIR from 0‐6 hours (AUCGIR.0‐6h), and partial AUCs (AUCGIR.0‐1h, AUCGIR.0‐2h and AUCGIR.2‐6h).ResultsHigher temperature (30°C) under 10% fixed humidity conditions resulted in greater GIRmax (P = 0.04) and a later tGIR.max (P = 0.049) compared to lower temperature (15°C). Humidity did not affect any pharmacodynamic parameter. When the combined effects of temperature and humidity were explored, tGIR.max (P = 0.008) occurred earlier, with a lower late insulin pharmacodynamic effect (AUCGIR.2‐6h; P = 0.017) at a temperature of 15°C and humidity of 10% compared to a temperature of 30°C and humidity of 60%.ConclusionsHigh ambient temperature resulted in a greater insulin peak effect compared to low ambient temperature, with the contribution of high relative humidity apparent only at high ambient temperature. This suggests that patients with type 1 diabetes mellitus who are entering higher environmental temperatures, with or without high humidity, could experience more hypoglycaemic events.