Description:
<jats:title>Abstract</jats:title><jats:p>The skin is our largest organ serving different tasks from barrier formation through somatosensing to hair development. Recently, members of the large <jats:italic>trp</jats:italic> (<jats:styled-content style="fixed-case">T</jats:styled-content>ransient <jats:styled-content style="fixed-case">R</jats:styled-content>eceptor <jats:styled-content style="fixed-case">P</jats:styled-content>otential, <jats:styled-content style="fixed-case">TRP</jats:styled-content>) gene family encoding proteins that form cation selective ion channel have been identified to play a crucial role in skin functions. Within the 28 different mammalian <jats:styled-content style="fixed-case">TRP</jats:styled-content> channels, <jats:styled-content style="fixed-case">TRPV</jats:styled-content>3 might be the most important member in the skin. This review gives an overview on functional properties of <jats:styled-content style="fixed-case">TRPV</jats:styled-content>3 in skin physiology and in certain skin diseases.</jats:p>