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Media type:
E-Article
Title:
Autophagy is responsible for the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis thaliana
Contributor:
Thirumalaikumar, Venkatesh P.;
Wagner, Mateusz;
Balazadeh, Salma;
Skirycz, Aleksandra
Published:
Wiley, 2021
Published in:
The FEBS Journal, 288 (2021) 1, Seite 281-292
Language:
English
DOI:
10.1111/febs.15336
ISSN:
1742-464X;
1742-4658
Origination:
Footnote:
Description:
Proteogenic dipeptides are intermediates of proteolysis as well as an emerging class of small‐molecule regulators with diverse and often dipeptide‐specific functions. Herein, prompted by differential accumulation of dipeptides in a high‐density Arabidopsis thaliana time‐course stress experiment, we decided to pursue an identity of the proteolytic pathway responsible for the buildup of dipeptides under heat conditions. By querying dipeptide accumulation versus available transcript data, autophagy emerged as a top hit. To examine whether autophagy indeed contributes to the accumulation of dipeptides measured in response to heat stress, we characterized the loss‐of‐function mutants of crucial autophagy proteins to test whether interfering with autophagy would affect dipeptide accumulation in response to the heat treatment. This was indeed the case. This work implicates the involvement of autophagy in the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis.