Alberts, Catharina J.;
Jeske, Rima;
de Martel, Catherine;
den Hollander, Wouter J.;
Michel, Angelika;
Prins, Maria;
Snijder, Marieke B.;
Schim van der Loeff, Maarten F.;
Waterboer, Tim
Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study
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Media type:
E-Article
Title:
Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study
Contributor:
Alberts, Catharina J.;
Jeske, Rima;
de Martel, Catherine;
den Hollander, Wouter J.;
Michel, Angelika;
Prins, Maria;
Snijder, Marieke B.;
Schim van der Loeff, Maarten F.;
Waterboer, Tim
imprint:
Wiley, 2020
Published in:Helicobacter
Language:
English
DOI:
10.1111/hel.12687
ISSN:
1083-4389;
1523-5378
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p><jats:italic>Helicobacter pylori</jats:italic> prevalence varies greatly worldwide. We explored the prevalence of <jats:italic>H. pylori</jats:italic> and CagA seropositivity among adults aged 18‐44 years living in the Netherlands by ethnicity and migration status (first vs second generation).</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>Participants from six different ethnic groups were selected from the population‐based multi‐ethnic HELIUS study in Amsterdam, the Netherlands. Serum samples were tested for <jats:italic>H. pylori</jats:italic> antigens using a validated Luminex‐based multiplex serology assay. Prevalence ratios were estimated using Poisson regression analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 4683 participants aged 18‐44 years were randomly selected based on sex, ethnicity, and age. <jats:italic>H. pylori</jats:italic> seroprevalence was highest in the Ghanaian group (84%), followed by Moroccan (81%), Turkish (66%), African Surinamese (51%), South‐Asian Surinamese (48%), and Dutch (17%) participants. All ethnic minority groups had a significantly higher risk of being <jats:italic>H. pylori</jats:italic> seropositive compared to the Dutch group. This association was strongest among participants born outside the Netherlands (first generation), but was still significant and apparent among second‐generation participants. Among first‐generation participants, all groups, except the Moroccans, had a significantly higher proportion of individuals with a <jats:italic>cagA + H. pylori</jats:italic> strain compared to the Dutch participants.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p><jats:italic>Helicobacter pylori</jats:italic> seroprevalence among first‐generation migrants is high in the Netherlands and remains elevated among second‐generation migrants (ie, those born in the Netherlands). High exposure to <jats:italic>H. pylori</jats:italic>, and especially to the more virulent <jats:italic>cagA+</jats:italic> strain, highlights the need for tailored prevention of gastric diseases (notably peptic ulcers and cancers) among migrants.</jats:p></jats:sec>