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Hu, Dongzhi; Du, Changzheng; Xue, Weicheng; Dou, Fangyuan; Yao, Yunfeng; Gu, Jin

The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ‐specific for distant metastasis in colorectal cancer: a comparative study

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  • Media type: E-Article
  • Title: The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ‐specific for distant metastasis in colorectal cancer: a comparative study
  • Contributor: Hu, Dongzhi; Du, Changzheng; Xue, Weicheng; Dou, Fangyuan; Yao, Yunfeng; Gu, Jin
  • imprint: Wiley, 2013
  • Published in: Histopathology
  • Language: English
  • DOI: 10.1111/his.12127
  • ISSN: 0309-0167; 1365-2559
  • Keywords: General Medicine ; Histology ; Pathology and Forensic Medicine
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>Aims</jats:title><jats:p>The liver and lung are the organs most commonly affected by metastasis in colorectal cancer (<jats:styled-content style="fixed-case">CRC</jats:styled-content>), and the interaction of chemokines and chemokine receptors (<jats:styled-content style="fixed-case">CKR</jats:styled-content>s) plays an important role in the metastatic process. The aim of this study was to investigate the organ specificity of <jats:styled-content style="fixed-case">CKR</jats:styled-content>s in <jats:styled-content style="fixed-case">CRC</jats:styled-content> distant metastasis.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>Surgical specimens of primary tumours from 46 patients with metachronous distant metastases were retrieved retrospectively (20 lung metastases; 26 liver metastases). As a control, the records of 29 patients without distant metastases were randomly retrieved from our database, and their specimens were reassessed. The expression rates of <jats:styled-content style="fixed-case">CKR</jats:styled-content>s, including <jats:styled-content style="fixed-case">CCR</jats:styled-content>6, <jats:styled-content style="fixed-case">CXCR</jats:styled-content>2, and <jats:styled-content style="fixed-case">CXCR</jats:styled-content>4, were determined by immunohistochemistry, and were compared among the groups. The expression rates of <jats:styled-content style="fixed-case">CCR</jats:styled-content>6 and <jats:styled-content style="fixed-case">CXCR</jats:styled-content>2 were both significantly higher in the metastasis group than in the non‐metastasis group (<jats:italic>P</jats:italic> &lt; 0.05), but there was no statistical difference between the lung metastasis and liver metastasis subgroups. The expression of <jats:styled-content style="fixed-case">CXCR</jats:styled-content>4 was not significantly different between the metastasis and non‐metastasis groups. Multivariable analysis suggested that preoperative serum carcinoembryonic antigen level, <jats:styled-content style="fixed-case">CCR</jats:styled-content>6 and <jats:styled-content style="fixed-case">CXCR</jats:styled-content>2 were independent factors associated with distant metastasis.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The expression of <jats:styled-content style="fixed-case">CCR</jats:styled-content>6 and <jats:styled-content style="fixed-case">CXCR</jats:styled-content>2 in <jats:styled-content style="fixed-case">CRC</jats:styled-content> could predict metachronous distant metastasis, but they have no organ specificity for metastasis.</jats:p></jats:sec>