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Media type:
E-Article
Title:
Metastatic pancreatic ductal adenocarcinoma: diagnosis and treatment with a view to the future
Contributor:
Pokorny, Adrian M. J.;
Chin, Venessa T.;
Nagrial, Adnan M.;
Yip, Desmond;
Chantrill, Lorraine A.
imprint:
Wiley, 2018
Published in:Internal Medicine Journal
Language:
English
DOI:
10.1111/imj.13810
ISSN:
1444-0903;
1445-5994
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>Metastatic pancreatic ductal adenocarcinoma (mPDAC) is a lethal disease with a poor 5‐year survival. Systemic treatments can be used to control symptoms and prolong life. Cytotoxic chemotherapies are commonly administered, with combination treatments, such as fluorouracil, folinic acid, irinotecan and oxaliplatin (FOLFIRINOX) or nab‐paclitaxel and gemcitabine showing the largest clinical benefits. Newer genomic classifications of PDAC may provide a rationale for targeted therapies or immunotherapies, although at present these remain largely experimental. This review discusses the evidence behind the currently used regimens, while introducing the potential future of pancreatic cancer care.</jats:p>