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Hogan, Benedikt; Ammer, Luise; Zimmermann, Marlow; Binger, Tabea; Krumkamp, Ralf; Sarpong, Nimako; Rettig, Theresa; Dekker, Denise; Kreuels, Benno; Reigl, Lisa; Boahen, Kennedy G.; Wiafe, Charity; Adu‐Sarkodie, Yaw; Owusu‐Dabo, Ellis; May, Jürgen; Eibach, Daniel

Burden of influenza among hospitalized febrile children in Ghana

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  • Media type: E-Article
  • Title: Burden of influenza among hospitalized febrile children in Ghana
  • Contributor: Hogan, Benedikt; Ammer, Luise; Zimmermann, Marlow; Binger, Tabea; Krumkamp, Ralf; Sarpong, Nimako; Rettig, Theresa; Dekker, Denise; Kreuels, Benno; Reigl, Lisa; Boahen, Kennedy G.; Wiafe, Charity; Adu‐Sarkodie, Yaw; Owusu‐Dabo, Ellis; May, Jürgen; Eibach, Daniel
  • Published: Wiley, 2017
  • Published in: Influenza and Other Respiratory Viruses, 11 (2017) 6, Seite 497-501
  • Language: English
  • DOI: 10.1111/irv.12507
  • ISSN: 1750-2640; 1750-2659
  • Keywords: Infectious Diseases ; Public Health, Environmental and Occupational Health ; Pulmonary and Respiratory Medicine ; Epidemiology
  • Origination:
  • University thesis:
  • Footnote:
  • Description: <jats:sec><jats:title>Background</jats:title><jats:p>Influenza surveillance data from Africa indicate a substantial disease burden with high mortality. However, local influenza data from district hospitals with limited laboratory facilities are still scarce.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>To identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Between January 2014 and April 2015, all children with a temperature of ≥38°C admitted to a district hospital in Ghana were screened for influenza A and B by <jats:styled-content style="fixed-case">RT</jats:styled-content>‐<jats:styled-content style="fixed-case">PCR</jats:styled-content> and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 1063 children with a median age of 2 years (<jats:styled-content style="fixed-case">IQR</jats:styled-content>: 1‐4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (<jats:styled-content style="fixed-case">SARI</jats:styled-content>) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09, and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3‐5 years and was more frequently detected in the major rainy season (<jats:styled-content style="fixed-case">OR</jats:styled-content> = 2.9; 95% <jats:styled-content style="fixed-case">CI</jats:styled-content>: 1.47‐6.19) during the first half of the year. Two (4%) and seven (15%) influenza‐positive children were co‐diagnosed with an invasive bloodstream infection or malaria, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Influenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half‐year.</jats:p></jats:sec>
  • Access State: Open Access