Description:
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<jats:list-item><jats:p>Starting from <jats:italic>trans</jats:italic>‐cinnamic acid a chiral (−)3‐phenyl‐[2,3‐<jats:sup>2</jats:sup>H]propionic acid has been synthesized using <jats:italic>Clostridium kluyveri</jats:italic> cells as catalyst.</jats:p></jats:list-item>
<jats:list-item><jats:p>The chiral dideuterated acid has been converted by chemical methods to a mixture of (2R) and (2S)‐phenyl[2,3‐<jats:sup>2</jats:sup>H]‐alanine.</jats:p></jats:list-item>
<jats:list-item><jats:p>By means of <jats:sup>1</jats:sup>H nuclear magnetic resonance spectroscopy and the action of D and L‐amino‐acid oxidase the configuration of the phenylalanine has been shown to be (2<jats:italic>R</jats:italic>, 3<jats:italic>S</jats:italic>) and (2<jats:italic>S</jats:italic>, 3<jats:italic>S</jats:italic>), respectively. The labelled phenylalanine is thus sterically and isotopically homogeneous at position 3 but heterogeneous at position 2.</jats:p></jats:list-item>
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