Development of the γ‐Aminobutyric Acid Neurotransmitter System in the Rat Cerebral Cortex During Repeated Administration of the GABA‐Transaminase Inhibitor Ethanolamine O‐Sulphate
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Media type:
E-Article
Title:
Development of the γ‐Aminobutyric Acid Neurotransmitter System in the Rat Cerebral Cortex During Repeated Administration of the GABA‐Transaminase Inhibitor Ethanolamine O‐Sulphate
Contributor:
Sykes, Clare C.;
Horton, Roger W.
Published:
Wiley, 1986
Published in:
Journal of Neurochemistry, 46 (1986) 1, Seite 213-217
Description:
Abstract: Ethanolamine O‐sulphate (400 mg/kg, i.p.) was administered to rat pups at 9 days of age and on alternate days up to 17 days of age. At 18 days of age, β‐aminobutyric acid (GABA) concentration was increased (three‐to fourfold), glutamic acid decarboxylase (GAD) activity reduced to 55% of control, and the number of GABAA and GABAB binding sites increased in the cerebral cortex. This is the same pattern of change as seen previously with oral administration of ethanolamine O‐sulphate to the adult rat but the changes occur more rapidly in the developing rat. A lower dose of ethanolamine O‐sulphate (100 mg/kg, i.p.), administered according to the same schedule, caused a twofold increase in cortical GABA at 18 days of age whereas GAD activity and GABAA binding were not significantly altered.