Palmer, James B.D.;
Cuss, Francis M.C.;
Mulderry, Peter K.;
Ghatei, Mohamed A.;
Springall, David R.;
Cadieux, Alain;
Bloom, Stephen R.;
Polak, Julia M.;
Barnes, Peter J.
Calcitonin gene‐related peptide is localised to human airway nerves and potently constricts human airway smooth muscle
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Media type:
E-Article
Title:
Calcitonin gene‐related peptide is localised to human airway nerves and potently constricts human airway smooth muscle
Contributor:
Palmer, James B.D.;
Cuss, Francis M.C.;
Mulderry, Peter K.;
Ghatei, Mohamed A.;
Springall, David R.;
Cadieux, Alain;
Bloom, Stephen R.;
Polak, Julia M.;
Barnes, Peter J.
Published:
Wiley, 1987
Published in:
British Journal of Pharmacology, 91 (1987) 1, Seite 95-101
Description:
<jats:p><jats:list list-type="explicit-label">
<jats:list-item><jats:p>In human airways synthetic human sequence calcitonin gene‐related peptide (hCGRP), a novel peptide produced by alternative processing of mRNA from the calcitonin gene, caused concentration‐dependent contraction of human bronchi (EC<jats:sub>50</jats:sub> 4.9 × 10<jats:sup>−9</jats:sup> <jats:sc>m</jats:sc>) and was significantly more potent than substance P or carbachol.</jats:p></jats:list-item>
<jats:list-item><jats:p>The contractile response was unaffected by atropine (2 × 10<jats:sup>−6</jats:sup> <jats:sc>m</jats:sc>), propranolol (10<jats:sup>−6</jats:sup> <jats:sc>m</jats:sc>), indomethacin (10<jats:sup>−5</jats:sup> <jats:sc>m</jats:sc>), tetrodotoxin (3 × 10<jats:sup>−6</jats:sup> <jats:sc>m</jats:sc>), chlorpheniramine (10<jats:sup>−4</jats:sup> <jats:sc>m</jats:sc>), cimetidine (10<jats:sup>−5</jats:sup> <jats:sc>m</jats:sc>), or FPL55712 (10<jats:sup>−4</jats:sup> <jats:sc>m</jats:sc>) suggesting a direct effect of CGRP on airways smooth muscle.</jats:p></jats:list-item>
<jats:list-item><jats:p>CGRP was detected in human airways by radioimmunoassay with highest concentrations in cartilaginous airways.</jats:p></jats:list-item>
<jats:list-item><jats:p>CGRP was localised by immunocytochemistry to both nerves and ganglia in human airways.</jats:p></jats:list-item>
<jats:list-item><jats:p>CGRP, is a potent constrictor of human airways and may have important effects on airway function and be implicated in the pathogenesis of bronchial hyper‐responsiveness and asthma.</jats:p></jats:list-item>
</jats:list></jats:p>