Effects of chronic oral administration of the antidepressants, desmethylimipramine and zimelidine on rat cortical GABAB binding sites: a comparison with 5‐HT2 binding site changes
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Media type:
E-Article
Title:
Effects of chronic oral administration of the antidepressants, desmethylimipramine and zimelidine on rat cortical GABAB binding sites: a comparison with 5‐HT2 binding site changes
Contributor:
Cross, Jacqueline A.;
Horton, Roger W.
Published:
Wiley, 1988
Published in:
British Journal of Pharmacology, 93 (1988) 2, Seite 331-336
Description:
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<jats:list-item><jats:p>The effects of chronic oral administration of desmethylimipramine (DMI) or zimelidine (1.25 and 5 mg kg<jats:sup>−1</jats:sup> twice daily for 21 days) were studied on rat whole cortical γ‐aminobutyric acid<jats:sub>B</jats:sub> (GABA<jats:sub>B</jats:sub>) binding sites. No changes in receptor affinity or number were found with either drug.</jats:p></jats:list-item>
<jats:list-item><jats:p>A subsequent study of GABA<jats:sub>B</jats:sub> binding sites using higher doses of these drugs (5 and 10 mg kg<jats:sup>−1</jats:sup>) and rat frontal cortex was also without effect, when investigated 24 h after termination of drug administration or 72 h after DMI administration (5 mg kg<jats:sup>−1</jats:sup>).</jats:p></jats:list-item>
<jats:list-item><jats:p>The number of frontal cortical 5‐hydroxytryptamine<jats:sub>2</jats:sub> (5‐HT<jats:sub>2</jats:sub>) binding sites was significantly and dose‐dependently decreased after both drugs, whereas the number of hippocampal 5‐HT<jats:sub>2</jats:sub> binding sites was not significantly altered after either drug.</jats:p></jats:list-item>
<jats:list-item><jats:p>As the number of frontal cortical GABA<jats:sub>B</jats:sub> binding sites was unaltered whereas the number of 5‐HT<jats:sub>2</jats:sub> binding sites was significantly decreased under identical study conditions, it may be concluded that the effects of antidepressant administration upon GABA<jats:sub>B</jats:sub> binding sites is a less consistent observation than their effects on 5‐HT<jats:sub>2</jats:sub> binding sites.</jats:p></jats:list-item>
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