Description:
<jats:title>Abstract</jats:title><jats:p>Today there is evidence that <jats:italic>Helicobacter pylori</jats:italic> has a critical role in different extragastric diseases. The discovery of a number of other novel <jats:italic>Helicobacter</jats:italic> species has stimulated the research in different extragastric diseases, in which an infectious hypothesis is plausible. Enterohepatic <jats:italic>Helicobacter</jats:italic> species have been hypothesized to play a role in different disorders, including hepatocellular carcinoma, gallstones formation and cholangiocellular carcinoma, as well as enteric diseases and inflammatory bowel diseases. Concerning the extragastric manifestations of <jats:italic>H. pylori</jats:italic> infection, idiopathic thrombocytopenic purpura, and sideropenic anemia represent, based on the current data, the diseases in which the pathogenic link appears to be strongest. There is also an increasing evidence for a possible association of <jats:italic>H. pylori</jats:italic> with cardiovascular disease.</jats:p>