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Media type:
E-Article
Title:
Contact photoallergy testing of sunscreens in guinea pigs
Contributor:
Frank Gerberick, G.;
Ryan, Cindy A.
Published:
Wiley, 1989
Published in:
Contact Dermatitis, 20 (1989) 4, Seite 251-259
Language:
English
DOI:
10.1111/j.1600-0536.1989.tb03141.x
ISSN:
0105-1873;
1600-0536
Origination:
Footnote:
Description:
The potential of 3 sunscreens (p‐aminobenzoic acid, 4‐isopropyldibenzoylmethane and homosalate) and 2 known human photoallergens (musk ambrette and tetrachlorosalicylanilide) to cause photoallergy, phototoxicity, and/or contact sensitization was determined using a guinea pig photoallergy model, as previously described by Harber and associates. The model was slightly modified by employing 6 exposures over 2 weeks and using Hill Top Chambers® for application of the test material. Contact photoallergy was detected in guinea pigs treated with musk ambrette or tetrachlorosalicylanilide (TCSA), although with TCSA, a lower incidence of contact sensitivity and phototoxicity was also detected. The results of studies conducted with sunscreens showed that p–aminobenzoic acid was photoallergenic, whereas homosalate and 4‐isopropyl‐dibenzoylmethane (Eusolex® 8020) were not. However, contact sensitization, and to a lesser degree primary irritation, was detected with Eusolex® 8020 at the concentrations employed in this study. The results of these studies suggest that this guinea pig model is a suitable model for assessing the photoallergic potential of various compounds, including the sunscreens tested in this study.