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Kagen, Mark; Cao, Lauren Y.; Oyetakin‐White, Patricia; Tacastacas, Joselin D.; Yan, Chunlin; McCormick, Thomas S.; Cooper, Kevin D.

Single administration of lesion‐limited high‐dose (TURBO) ultraviolet B using the excimer laser: clinical clearing in association with apoptosis of epidermal and dermal T cell subsets in psoriasis

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  • Media type: E-Article
  • Title: Single administration of lesion‐limited high‐dose (TURBO) ultraviolet B using the excimer laser: clinical clearing in association with apoptosis of epidermal and dermal T cell subsets in psoriasis
  • Contributor: Kagen, Mark; Cao, Lauren Y.; Oyetakin‐White, Patricia; Tacastacas, Joselin D.; Yan, Chunlin; McCormick, Thomas S.; Cooper, Kevin D.
  • imprint: Wiley, 2012
  • Published in: Photodermatology, Photoimmunology & Photomedicine
  • Language: English
  • DOI: 10.1111/j.1600-0781.2012.00692.x
  • ISSN: 0905-4383; 1600-0781
  • Origination:
  • Footnote:
  • Description: <jats:title>Summary</jats:title><jats:sec><jats:title>Background/Purpose</jats:title><jats:p>Development of effective therapy for psoriasis is confounded by numerous factors contributing to disease pathogenesis, including pathogenic immunocytes which appear to drive epidermal keratinocyte hyperproliferation. Our objective was to study clinical and biomarker effects of a single dose of <jats:styled-content style="fixed-case">TURBO</jats:styled-content> laser <jats:styled-content style="fixed-case">UVB</jats:styled-content> (308 nm) applied directly to psoriatic plaques.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Eighteen patients with chronic plaque psoriasis received a single dose of 10 minimal erythema dose (<jats:styled-content style="fixed-case">MED</jats:styled-content>) <jats:styled-content style="fixed-case">UVB</jats:styled-content> and were followed for 8 weeks. Keratome and punch biopsies were assessed for <jats:styled-content style="fixed-case">T</jats:styled-content> cell depletion and apoptosis following a single 308‐nm dose of <jats:styled-content style="fixed-case">UVB</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Patients demonstrated clinical improvement as indicated by decreased global <jats:styled-content style="fixed-case">P</jats:styled-content>soriasis <jats:styled-content style="fixed-case">A</jats:styled-content>rea and <jats:styled-content style="fixed-case">S</jats:styled-content>everity <jats:styled-content style="fixed-case">I</jats:styled-content>ndex scores and reduced numbers of pathogenic memory/effector <jats:styled-content style="fixed-case">T</jats:styled-content> cells infiltrating lesional epidermis and dermis. Consistent with apoptosis induction, caspase activation increased in lesional <jats:styled-content style="fixed-case">T</jats:styled-content> cells after treatment.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>We conclude that a single 10 <jats:styled-content style="fixed-case">MED</jats:styled-content> dose of <jats:styled-content style="fixed-case">TURBO UVB</jats:styled-content> is effective at reducing the severity and extent of psoriatic lesions. We hypothesize that the reason a single treatment is sufficient to clear a psoriatic plaque is that the 10 <jats:styled-content style="fixed-case">MED</jats:styled-content> dose is able to deliver sufficient photons to a microanatomic area of the lesion where susceptible pathogenic <jats:styled-content style="fixed-case">T</jats:styled-content> cell mechanisms are operative.</jats:p></jats:sec>