Description:
<jats:p>A series of disubstituted 4(3H) quinazolines were designed for potential application in tumors. Firstly, <jats:italic>N</jats:italic>‐benzoyl anthranilic acid is formed, which undergoes cyclization in the presence of pyridine. Subsequently, nucleophilic attack by semicarbazide on the carbonyl carbon gives 2‐substituted 3‐carbamido 4(3H) quinazolones, which gives final compound with appropriate substitution. The final as well as intermediate products were confirmed by NMR, FT‐IR, and mass spectrometry. <jats:italic>In vitro</jats:italic> toxicity was performed with different cell lines and showed that the connection of hydrophilic styryl to quinazoline moiety increases its efficacy.</jats:p>