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Media type:
E-Article
Title:
Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence
Contributor:
Contet, Candice;
Gardon, Olivier;
Filliol, Dominique;
Becker, Jérôme A. J.;
Koob, George F.;
Kieffer, Brigitte L.
Published:
Wiley, 2011
Published in:
Addiction Biology, 16 (2011) 4, Seite 615-619
Language:
English
DOI:
10.1111/j.1369-1600.2010.00304.x
ISSN:
1355-6215;
1369-1600
Origination:
Footnote:
Description:
ABSTRACTAlcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non‐dependent mice maintaining a stable voluntary consumption or mice solely undergoing forced intoxication. We measured expression levels of 106 candidate genes in the extended amygdala, a key brain structure for the development of drug addiction. Cluster analysis identified 17 and 15 genes selectively induced or repressed, respectively, under conditions of excessive drinking. These genes belong to signaling pathways involved in neurotransmission and transcriptional regulation.