You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Corticosterone and prolactin response to TFMPP in rats during repeated antidepressant administration
Contributor:
Poland, Russell E;
Frazer, Alan
Published:
Oxford University Press (OUP), 2011
Published in:
Journal of Pharmacy and Pharmacology, 43 (2011) 1, Seite 54-56
Language:
English
DOI:
10.1111/j.2042-7158.1991.tb05450.x
ISSN:
2042-7158;
0022-3573
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>The corticosterone and prolactin response to acute administration of the 5-HT agonist 1-(m-trifluoromethylphenyl) piperazine (TFMPP) (10 mg kg−1) was assessed in rats treated for 10 days with either saline, amitriptyline (20 mg kg−1 day−1) or nialamide (40 mg kg−1 day−1). For all groups, TFMPP significantly increased both serum corticosterone and prolactin concentrations compared with control animals challenged with saline. However, the corticosterone response to TFMPP was attenuated significantly by nialamide pretreatment, while the prolactin response to TFMPP was enhanced significantly by amitriptyline pretreatment. These results support previous reports that antidepressants differentially affect 5-HT-ergic systems involved in the regulation of corticosterone and prolactin secretion.</jats:p>