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Media type:
E-Article
Title:
Spatially resolved mass spectrometry analysis of amyloid plaque‐associated lipids
Contributor:
Blank, Martina;
Hopf, Carsten
imprint:
Wiley, 2021
Published in:Journal of Neurochemistry
Language:
English
DOI:
10.1111/jnc.15216
ISSN:
0022-3042;
1471-4159
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Over the last 10 years, considerable technical advances in mass spectrometry (MS)‐based bioanalysis have enabled the investigation of lipid signatures in neuropathological structures. In Alzheimer´s Disease (AD) research, it is now well accepted that lipid dysregulation plays a key role in AD pathogenesis and progression. This review summarizes current MS‐based strategies, notably MALDI and ToF‐SIMS imaging as well as laser capture microdissection combined with LC‐ESI‐MS. It also presents recent advances to assess lipid alterations associated with Amyloid‐β plaques, one of the hallmarks of AD. Collectively, these methodologies offer new opportunities for the study of lipids, thus pushing forward our understanding of their role in such a complex and still untreatable disease as AD.</jats:p></jats:sec><jats:sec><jats:label /><jats:p>
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