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Tran, Van‐Tuan; Braus‐Stromeyer, Susanna A.; Kusch, Harald; Reusche, Michael; Kaever, Alexander; Kühn, Anika; Valerius, Oliver; Landesfeind, Manuel; Aßhauer, Kathrin; Tech, Maike; Hoff, Katharina; Pena‐Centeno, Tonatiuh; Stanke, Mario; Lipka, Volker; Braus, Gerhard H.

Verticillium transcription activator of adhesion Vta2 suppresses microsclerotia formation and is required for systemic infection of plant roots

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  • Media type: E-Article
  • Title: Verticillium transcription activator of adhesion Vta2 suppresses microsclerotia formation and is required for systemic infection of plant roots
  • Contributor: Tran, Van‐Tuan; Braus‐Stromeyer, Susanna A.; Kusch, Harald; Reusche, Michael; Kaever, Alexander; Kühn, Anika; Valerius, Oliver; Landesfeind, Manuel; Aßhauer, Kathrin; Tech, Maike; Hoff, Katharina; Pena‐Centeno, Tonatiuh; Stanke, Mario; Lipka, Volker; Braus, Gerhard H.
  • imprint: Wiley, 2014
  • Published in: New Phytologist
  • Language: English
  • DOI: 10.1111/nph.12671
  • ISSN: 0028-646X; 1469-8137
  • Origination:
  • Footnote:
  • Description: <jats:title>Summary</jats:title><jats:p> <jats:list list-type="bullet"> <jats:list-item><jats:p>Six transcription regulatory genes of the <jats:italic><jats:styled-content style="fixed-case">V</jats:styled-content>erticillium</jats:italic> plant pathogen, which reprogrammed nonadherent budding yeasts for adhesion, were isolated by a genetic screen to identify control elements for early plant infection.</jats:p></jats:list-item> <jats:list-item><jats:p><jats:italic><jats:styled-content style="fixed-case">V</jats:styled-content>erticillium</jats:italic> transcription activator of adhesion <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 is highly conserved in filamentous fungi but not present in yeasts. The <jats:italic><jats:styled-content style="fixed-case">M</jats:styled-content>agnaporthe grisea</jats:italic> ortholog conidiation regulator <jats:styled-content style="fixed-case">C</jats:styled-content>on7 controls the formation of appressoria which are absent in <jats:italic><jats:styled-content style="fixed-case">V</jats:styled-content>erticillium</jats:italic> species. <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 was analyzed by using genetics, cell biology, transcriptomics, secretome proteomics and plant pathogenicity assays.</jats:p></jats:list-item> <jats:list-item><jats:p>Nuclear <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 activates the expression of the adhesin‐encoding yeast flocculin genes <jats:italic><jats:styled-content style="fixed-case">FLO</jats:styled-content>1</jats:italic> and <jats:italic><jats:styled-content style="fixed-case">FLO</jats:styled-content>11</jats:italic>. <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 is required for fungal growth of <jats:italic><jats:styled-content style="fixed-case">V</jats:styled-content>erticillium</jats:italic> where it is a positive regulator of conidiation. <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 is mandatory for accurate timing and suppression of microsclerotia as resting structures. <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 controls expression of 270 transcripts, including 10 putative genes for adhesins and 57 for secreted proteins. <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 controls the level of 125 secreted proteins, including putative adhesins or effector molecules and a secreted catalase‐peroxidase. <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 is a major regulator of fungal pathogenesis, and controls host‐plant root infection and <jats:styled-content style="fixed-case">H</jats:styled-content><jats:sub>2</jats:sub><jats:styled-content style="fixed-case">O</jats:styled-content><jats:sub>2</jats:sub> detoxification.</jats:p></jats:list-item> <jats:list-item><jats:p><jats:italic><jats:styled-content style="fixed-case">V</jats:styled-content>erticillium</jats:italic> impaired in <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 is unable to colonize plants and induce disease symptoms. <jats:styled-content style="fixed-case">V</jats:styled-content>ta2 represents an interesting target for controlling the growth and development of these vascular pathogens.</jats:p></jats:list-item> </jats:list> </jats:p>
  • Access State: Open Access