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Abdallah, Marwa; El‐Mofty, Medhat; Anbar, Tag; Rasheed, Hoda; Esmat, Samia; Al‐Tawdy, Amira; Fawzy, Marwa M.; Abdel‐Halim, Dalia; Hegazy, Rehab; Gawdat, Heba; Bassiouny, Dalia; Ibrahim, Mona A.; Sany, Iman; El‐Bassiouny, Mahy; Khalil, Mohamed; Abdel‐Aziz, Abeer; El Maadawi, Zeinab M.; Mostafa, Wedad Z.

CXCL‐10 and Interleukin‐6 are reliable serum markers for vitiligo activity: A multicenter cross‐sectional study

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  • Media type: E-Article
  • Title: CXCL‐10 and Interleukin‐6 are reliable serum markers for vitiligo activity: A multicenter cross‐sectional study
  • Contributor: Abdallah, Marwa; El‐Mofty, Medhat; Anbar, Tag; Rasheed, Hoda; Esmat, Samia; Al‐Tawdy, Amira; Fawzy, Marwa M.; Abdel‐Halim, Dalia; Hegazy, Rehab; Gawdat, Heba; Bassiouny, Dalia; Ibrahim, Mona A.; Sany, Iman; El‐Bassiouny, Mahy; Khalil, Mohamed; Abdel‐Aziz, Abeer; El Maadawi, Zeinab M.; Mostafa, Wedad Z.
  • imprint: Wiley, 2018
  • Published in: Pigment Cell & Melanoma Research
  • Language: English
  • DOI: 10.1111/pcmr.12667
  • ISSN: 1755-1471; 1755-148X
  • Keywords: Dermatology ; General Biochemistry, Genetics and Molecular Biology ; Oncology
  • Origination:
  • Footnote:
  • Description: <jats:title>Summary</jats:title><jats:p>This cross‐sectional multicenter study aimed to evaluate serum <jats:styled-content style="fixed-case">CXCL</jats:styled-content>‐10, as an activity marker for vitiligo, and compare it with other putative serum and tissue markers. Serum <jats:styled-content style="fixed-case">CXCL</jats:styled-content>‐10 was compared to interferon gamma (<jats:styled-content style="fixed-case">IFN</jats:styled-content>‐γ), interleukin 6 (<jats:styled-content style="fixed-case">IL</jats:styled-content>‐6), and <jats:styled-content style="fixed-case">IL</jats:styled-content>‐17 using <jats:styled-content style="fixed-case">ELISA</jats:styled-content> in 55 non‐segmental vitiligo patients (30 active and 25 stable) and 30 healthy controls. Marginal skin biopsy was taken for immunohistochemical evaluation of <jats:styled-content style="fixed-case">CD</jats:styled-content>8+T cells and <jats:styled-content style="fixed-case">CXCL</jats:styled-content>‐10+ve cells. Serum levels of <jats:styled-content style="fixed-case">CXCL</jats:styled-content>‐10, <jats:styled-content style="fixed-case">IL</jats:styled-content>‐17, and <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 were elevated in all vitiligo patients compared to controls (<jats:italic>p</jats:italic> &lt; .05). All investigated serum markers were higher in active versus stable vitiligo. Tissue expression of <jats:styled-content style="fixed-case">CXCL</jats:styled-content>‐10+ve cells and <jats:styled-content style="fixed-case">CD</jats:styled-content>8+ve T cells was stronger in vitiligo patients compared to controls, and tissue <jats:styled-content style="fixed-case">CXCL</jats:styled-content>‐10+ve cell expression was stronger in active versus stable cases. Positive correlations were noted between the different serum and tissue markers. <jats:styled-content style="fixed-case">CXCL</jats:styled-content>‐10 was the most specific, whereas <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 was the most sensitive serum marker to distinguish active from stable disease.</jats:p>