Rasse‐Suriani, Federico A. O.;
García‐Einschlag, Fernando S.;
Rafti, Matías;
Schmidt De León, Tobías;
David Gara, Pedro M.;
Erra‐Balsells, Rosa;
Cabrerizo, Franco M.
Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)‐ and/or N(9)‐methyl‐β‐carboline Derivatives
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Media type:
E-Article
Title:
Photophysical and Photochemical Properties of Naturally Occurring normelinonine F and Melinonine F Alkaloids and Structurally Related N(2)‐ and/or N(9)‐methyl‐β‐carboline Derivatives
Contributor:
Rasse‐Suriani, Federico A. O.;
García‐Einschlag, Fernando S.;
Rafti, Matías;
Schmidt De León, Tobías;
David Gara, Pedro M.;
Erra‐Balsells, Rosa;
Cabrerizo, Franco M.
imprint:
Wiley, 2018
Published in:Photochemistry and Photobiology
Language:
English
DOI:
10.1111/php.12811
ISSN:
0031-8655;
1751-1097
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title><jats:p>In the present work, we have synthesized and fully characterized the photophysical and photochemical properties of a selected group of N‐methyl‐<jats:italic>β</jats:italic>‐carboline derivatives (9‐methyl‐<jats:italic>β</jats:italic>‐carbolines and iodine salts of 2‐methyl‐ and 2,9‐dimethyl‐<jats:italic>β</jats:italic>‐carbolinium) in aqueous solutions, in the <jats:styled-content style="fixed-case">pH</jats:styled-content> range 4.0–14.5. Moreover, despite the quite extensive studies reported in the literature regarding the overall photophysical behavior of N‐unsubstituted <jats:italic>β</jats:italic>Cs, this work constitutes the first full and unambiguous characterization of anionic species of N‐unsubstituted <jats:italic>β</jats:italic>Cs (<jats:italic>nor</jats:italic>harmane, harmane and harmine), present in aqueous solution under highly alkaline conditions (<jats:styled-content style="fixed-case">pH</jats:styled-content> > 13.0). Acid dissociation constants (<jats:italic>K</jats:italic><jats:sub>a</jats:sub>), thermal stabilities, room temperature <jats:styled-content style="fixed-case">UV</jats:styled-content>–visible absorption and fluorescence emission and excitation spectra, fluorescence quantum yields (<jats:italic>Ф</jats:italic><jats:sub>F</jats:sub>) and fluorescence lifetimes (<jats:italic>τ</jats:italic><jats:sub>F</jats:sub>), as well as quantum yields of singlet oxygen production (<jats:italic>Ф</jats:italic><jats:sub>Δ</jats:sub>) have been measured for all the studied compounds. Furthermore, for the first time to our knowledge, chemometric techniques (<jats:styled-content style="fixed-case">MCR</jats:styled-content>‐<jats:styled-content style="fixed-case">ALS</jats:styled-content> and <jats:styled-content style="fixed-case">PARAFAC</jats:styled-content>) were applied on these systems, providing relevant information about the equilibria and species involved. The impact of all the foregoing observations on the biological role, as well as the potential biotechnological applications of these compounds, is discussed.</jats:p>