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Teles, Leandro de Freitas; Viana, Agostinho Gonçalves; Cardoso, Mariana Santos; Pinheiro, Guilherme Rafael Gomide; Bento, Gabriele Ariadine; Lula, Jamille Fernandes; Soares, Tânia de Cássia Moreira; Fujiwara, Ricardo Toshio; Carvalho, Silvio Fernando Guimarães de

Evaluation of medullary cytokine expression and clinical and laboratory aspects in severe human visceral leishmaniasis

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  • Media type: E-Article
  • Title: Evaluation of medullary cytokine expression and clinical and laboratory aspects in severe human visceral leishmaniasis
  • Contributor: Teles, Leandro de Freitas; Viana, Agostinho Gonçalves; Cardoso, Mariana Santos; Pinheiro, Guilherme Rafael Gomide; Bento, Gabriele Ariadine; Lula, Jamille Fernandes; Soares, Tânia de Cássia Moreira; Fujiwara, Ricardo Toshio; Carvalho, Silvio Fernando Guimarães de
  • Published: Wiley, 2021
  • Published in: Parasite Immunology, 43 (2021) 12
  • Language: English
  • DOI: 10.1111/pim.12880
  • ISSN: 0141-9838; 1365-3024
  • Keywords: Immunology ; Parasitology
  • Origination:
  • Footnote:
  • Description: AbstractBackgroundVisceral leishmaniasis (VL) is a serious public health problem. The factors that can determine whether VL develops and progresses to severe form have not been fully identified, but a specific cellular immune response appears to play a key role. Therefore, understanding immunopathogenesis can be useful in preventing a serious clinical outcome.Materials and MethodsBone marrow samples were collected from patients with severe VL (SVL) or non‐severe VL (NSVL). Cytokine levels and parasitic load were analysed by RT‐qPCR. There is a statistically significant difference in the leukocyte parameter in patients with SVL and NSVL compared with the control patients (p = .006 and p = .014, respectively).ResultsUrea, alanine transaminase and albumin parameters had a significant difference p = .036, p = .039 and p = .017, respectively, between SVL and NSVL. Although high levels of IFN‐γ, IL‐10, IL‐6 and TNF‐α were present in all groups of individuals with VL, they were not statistically associated with severity. In patients with active VL, IFN‐γ and IL‐10 were associated, respectively, with a reduction and increase in the parasite load, strong and significant positive association between IFN‐γ and IL‐10 (rho = .627 and p = .003).ConclusionThis study demonstrates that VL stimulates an non‐dichotomized inflammatory response between Th1/Th2 and that bone marrow is an important tissue for immune regulation.
  • Access State: Open Access