You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Novel instrumentation to determine peel force in vivo and preliminary studies with adhesive skin barriers
Contributor:
Krueger, Evan M.;
Cullum, Malford E.;
Nichols, Thom R.;
Taylor, Michael G.;
Sexton, William L.;
Murahata, Richard I.
Published:
Wiley, 2013
Published in:
Skin Research and Technology, 19 (2013) 4, Seite 398-404
Language:
English
DOI:
10.1111/srt.12059
ISSN:
0909-752X;
1600-0846
Origination:
Footnote:
Description:
Background/purposeAdhesive barriers secure medical devices to skin. Laboratory adhesion models are not predictive of in vivo performance. The objectives of these studies were to validate a novel peel force device, and to investigate relationships between barrier formulations, barrier width, subjective discomfort during barrier removal, and substrates.MethodsThree hydrocolloid barrier formulations in three widths were adhered to ethylene/methyl acrylate film (EMA), VITRO‐SKIN® and human abdominal skin. Peel force was measured using a MTS Insight™ and a cyberDERM Inc. Mini Peel Tester (CMPT). Subjects reported their discomfort.ResultsPeel forces were highly correlated between devices and highly dependent on substrate. Data suggested a weak direct association between peel force in vivo and discomfort. The 0.5″‐wide barriers had the most precise peel forces measurements in vivo. A weak negative relationship between normalized peel force and barrier width on human skin was found. There was a strong positive relationship between peel force in vivo and on EMA, whereas no correlation was observed with VITRO‐SKIN®.ConclusionThe CMPT correlates with a standard instrument and can advantageously investigate adhesion in vivo. Barrier width and substrate impact the reliability and predictability of peel force measurements.