You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli
Contributor:
Borisovska, Maria;
McGinley, Matthew J.;
Bensen, AeSoon;
Westbrook, Gary L.
imprint:
Wiley, 2011
Published in:The Journal of Physiology
Language:
English
DOI:
10.1113/jphysiol.2011.206276
ISSN:
0022-3751;
1469-7793
Origination:
Footnote:
Description:
<jats:p><jats:bold>Non‐technical summary </jats:bold> In olfactory bulb glomeruli, incoming sensory input from the nose (axodendritic synapses) is segregated from local intraglomerular interactions (dendrodendritic synapses). We examined the synchrony of neural activity within glomeruli using knockout mice in which loss of olfactory cell adhesion molecule disrupts clustering of synaptic compartments. Using paired whole‐cell recording of mitral cells within a single glomerulus in brain slices, synchrony of fast and slow neural activity was reduced. However, incoming afferent activity and dendrodendritic inhibition were unaffected. We suggest that compartmentalization of synapses in the glomerulus is important for processing of olfactory sensory information.</jats:p>