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Media type:
E-Article
Title:
Determinants of human cerebral pressure–flow velocity relationships: new insights from vascular modelling and Ca2+ channel blockade
Contributor:
Tzeng, Yu‐Chieh;
Chan, Gregory S. H.;
Willie, Christopher K.;
Ainslie, Philip N.
imprint:
Wiley, 2011
Published in:The Journal of Physiology
Language:
English
DOI:
10.1113/jphysiol.2011.206953
ISSN:
0022-3751;
1469-7793
Origination:
Footnote:
Description:
<jats:p><jats:bold>Non‐technical summary </jats:bold> Brain function is critically dependent on the regulation of cerebral blood flow (CBF) by cerebral blood vessels. We show that a mechanical blood vessel property called <jats:italic>compliance</jats:italic> plays an important role in determining the way cerebral blood vessels respond to changes in blood pressure. These results enhance our knowledge of how cerebral blood vessels regulate CBF, which is critical to understanding the causes and effects of cerebrovascular diseases such as stroke and dementia.</jats:p>