• Media type: E-Article
  • Title: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
  • Contributor: O’Rourke, Donald M.; Nasrallah, MacLean P.; Desai, Arati; Melenhorst, Jan J.; Mansfield, Keith; Morrissette, Jennifer J. D.; Martinez-Lage, Maria; Brem, Steven; Maloney, Eileen; Shen, Angela; Isaacs, Randi; Mohan, Suyash; Plesa, Gabriela; Lacey, Simon F.; Navenot, Jean-Marc; Zheng, Zhaohui; Levine, Bruce L.; Okada, Hideho; June, Carl H.; Brogdon, Jennifer L.; Maus, Marcela V.
  • imprint: American Association for the Advancement of Science (AAAS), 2017
  • Published in: Science Translational Medicine
  • Language: English
  • DOI: 10.1126/scitranslmed.aaa0984
  • ISSN: 1946-6234; 1946-6242
  • Origination:
  • Footnote:
  • Description: <jats:p>A trial of autologous T cells redirected to a specific mutation in glioblastoma patients illustrates mechanisms of resistance.</jats:p>