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Hagemann, Tracy L.; Powers, Berit; Lin, Ni-Hsuan; Mohamed, Ahmed F.; Dague, Katerina L.; Hannah, Seth C.; Bachmann, Gemma; Mazur, Curt; Rigo, Frank; Olsen, Abby L.; Feany, Mel B.; Perng, Ming-Der; Berman, Robert F.; Messing, Albee

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment

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  • Media type: E-Article
  • Title: Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment
  • Contributor: Hagemann, Tracy L.; Powers, Berit; Lin, Ni-Hsuan; Mohamed, Ahmed F.; Dague, Katerina L.; Hannah, Seth C.; Bachmann, Gemma; Mazur, Curt; Rigo, Frank; Olsen, Abby L.; Feany, Mel B.; Perng, Ming-Der; Berman, Robert F.; Messing, Albee
  • Published: American Association for the Advancement of Science (AAAS), 2021
  • Published in: Science Translational Medicine, 13 (2021) 620
  • Language: English
  • DOI: 10.1126/scitranslmed.abg4711
  • ISSN: 1946-6234; 1946-6242
  • Origination:
  • Footnote:
  • Description: Gfap -antisense prevents disease with early treatment and reverses clinical phenotypes with late treatment in a rat model of Alexander disease.