Published:
American Association for the Advancement of Science (AAAS), 2022
Published in:
Science Translational Medicine, 14 (2022) 670
Language:
English
DOI:
10.1126/scitranslmed.abo5409
ISSN:
1946-6234;
1946-6242
Origination:
Footnote:
Description:
Molecular insights into the mechanism of beneficial and adverse effects of interleukin-2 (IL-2) have resulted in the development of improved IL-2 formulations with IL-2 receptor bias and tissue-targeting properties. Several of these compounds are currently in clinical development and are ushering IL-2 therapy into the current era of cancer immunotherapy.