You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway
Contributor:
Riewald, Matthias;
Petrovan, Ramona J.;
Donner, Aaron;
Mueller, Barbara M.;
Ruf, Wolfram
imprint:
American Association for the Advancement of Science (AAAS), 2002
Published in:Science
Language:
English
DOI:
10.1126/science.1071699
ISSN:
0036-8075;
1095-9203
Origination:
Footnote:
Description:
<jats:p>The coagulant and inflammatory exacerbation in sepsis is counterbalanced by the protective protein C (PC) pathway. Activated PC (APC) was shown to use the endothelial cell PC receptor (EPCR) as a coreceptor for cleavage of protease activated receptor 1 (PAR1) on endothelial cells. Gene profiling demonstrated that PAR1 signaling could account for all APC-induced protective genes, including the immunomodulatory monocyte chemoattractant protein-1 (MCP-1), which was selectively induced by activation of PAR1, but not PAR2. Thus, the prototypical thrombin receptor is the target for EPCR-dependent APC signaling, suggesting a role for this receptor cascade in protection from sepsis.</jats:p>