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Media type:
E-Article
Title:
Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome
Contributor:
Lombardi, Vincent C.;
Ruscetti, Francis W.;
Das Gupta, Jaydip;
Pfost, Max A.;
Hagen, Kathryn S.;
Peterson, Daniel L.;
Ruscetti, Sandra K.;
Bagni, Rachel K.;
Petrow-Sadowski, Cari;
Gold, Bert;
Dean, Michael;
Silverman, Robert H.;
Mikovits, Judy A.
Published:
American Association for the Advancement of Science (AAAS), 2009
Published in:
Science, 326 (2009) 5952, Seite 585-589
Language:
English
DOI:
10.1126/science.1179052
ISSN:
0036-8075;
1095-9203
Origination:
Footnote:
Description:
Viral Link to Chronic Fatigue Chronic fatigue syndrome (CFS) is a complex and debilitating disorder that is often linked to immune system dysfunction but whose cause(s) remain mysterious. Lombardi et al. (p. 585 , published online 8 October; see the Perspective by Coffin and Stoye ) now present a tantalizing new lead. In blood samples from 101 patients with well-documented CFS, over two-thirds (68) contained DNA from a recently described human gammaretrovirus, xenotropic murine leukemia virus–related virus (XMRV), which possesses sequence similarity to a murine leukemia virus. Cell culture assays confirmed that XMRV derived from CFS patient plasma and from T and B lymphocytes was infectious. Although the correlation with CFS is striking, whether the virus plays a causal role in the disorder remains to be determined. Interestingly, nearly 4% of the 218 healthy donors tested were positive for XMRV, which suggests that this virus—whose pathogenic potential is unknown—may be present in a significant proportion of the general population.