• Media type: E-Article
  • Title: Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
  • Contributor: Carneiro, Miguel; Rubin, Carl-Johan; Di Palma, Federica; Albert, Frank W.; Alföldi, Jessica; Barrio, Alvaro Martinez; Pielberg, Gerli; Rafati, Nima; Sayyab, Shumaila; Turner-Maier, Jason; Younis, Shady; Afonso, Sandra; Aken, Bronwen; Alves, Joel M.; Barrell, Daniel; Bolet, Gerard; Boucher, Samuel; Burbano, Hernán A.; Campos, Rita; Chang, Jean L.; Duranthon, Veronique; Fontanesi, Luca; Garreau, Hervé; Heiman, David; [...]
  • imprint: American Association for the Advancement of Science (AAAS), 2014
  • Published in: Science
  • Language: English
  • DOI: 10.1126/science.1253714
  • ISSN: 0036-8075; 1095-9203
  • Origination:
  • Footnote:
  • Description: <jats:title>Rabbits softly swept to domestication</jats:title> <jats:p> When people domesticate animals, they select for tameness and tolerance of humans. What else do they look for? To identify the selective pressures that led to rabbit domestication, Carneiro <jats:italic>et al.</jats:italic> sequenced a domestic rabbit genome and compared it to that of its wild brethren (see the Perspective by Lohmueller). Domestication did not involve a single gene changing, but rather many gene alleles changing in frequency between tame and domestic rabbits, known as a soft selective sweep. Many of these alleles have changes that may affect brain development, supporting the idea that tameness involves changes at multiple loci. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6200" page="1074" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1253714">1074</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6200" page="1000" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1258775">1000</jats:related-article> </jats:p>