> Details

Zhang, Benyue; Chassaing, Benoit; Shi, Zhenda; Uchiyama, Robin; Zhang, Zhan; Denning, Timothy L.; Crawford, Sue E.; Pruijssers, Andrea J.; Iskarpatyoti, Jason A.; Estes, Mary K.; Dermody, Terence S.; Ouyang, Wenjun; Williams, Ifor R.; Vijay-Kumar, Matam; Gewirtz, Andrew T.

Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18
  • Contributor: Zhang, Benyue; Chassaing, Benoit; Shi, Zhenda; Uchiyama, Robin; Zhang, Zhan; Denning, Timothy L.; Crawford, Sue E.; Pruijssers, Andrea J.; Iskarpatyoti, Jason A.; Estes, Mary K.; Dermody, Terence S.; Ouyang, Wenjun; Williams, Ifor R.; Vijay-Kumar, Matam; Gewirtz, Andrew T.
  • Published: American Association for the Advancement of Science (AAAS), 2014
  • Published in: Science, 346 (2014) 6211, Seite 861-865
  • Language: English
  • DOI: 10.1126/science.1256999
  • ISSN: 0036-8075; 1095-9203
  • Origination:
  • Footnote:
  • Description: Activators of innate immunity may have the potential to combat a broad range of infectious agents. We report that treatment with bacterial flagellin prevented rotavirus (RV) infection in mice and cured chronically RV-infected mice. Protection was independent of adaptive immunity and interferon (IFN, type I and II) and required flagellin receptors Toll-like receptor 5 (TLR5) and NOD-like receptor C4 (NLRC4). Flagellin-induced activation of TLR5 on dendritic cells elicited production of the cytokine interleukin-22 (IL-22), which induced a protective gene expression program in intestinal epithelial cells. Flagellin also induced NLRC4-dependent production of IL-18 and immediate elimination of RV-infected cells. Administration of IL-22 and IL-18 to mice fully recapitulated the capacity of flagellin to prevent or eliminate RV infection and thus holds promise as a broad-spectrum antiviral agent.