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Media type:
E-Article
Title:
PIP 2 and PIP as Determinants for ATP Inhibition of K ATP Channels
Contributor:
Baukrowitz, Thomas;
Schulte, Uwe;
Oliver, Dominik;
Herlitze, Stefan;
Krauter, Tobias;
Tucker, Stephen J.;
Ruppersberg, J. Peter;
Fakler, Bernd
imprint:
American Association for the Advancement of Science (AAAS), 1998
Published in:Science
Language:
English
DOI:
10.1126/science.282.5391.1141
ISSN:
0036-8075;
1095-9203
Origination:
Footnote:
Description:
<jats:p>
Adenosine triphosphate (ATP)–sensitive potassium (K
<jats:sub>ATP</jats:sub>
) channels couple electrical activity to cellular metabolism through their inhibition by intracellular ATP. ATP inhibition of K
<jats:sub>ATP</jats:sub>
channels varies among tissues and is affected by the metabolic and regulatory state of individual cells, suggesting involvement of endogenous factors. It is reported here that phosphatidylinositol-4,5-bisphosphate (PIP
<jats:sub>2</jats:sub>
) and phosphatidylinositol-4-phosphate (PIP) controlled ATP inhibition of cloned K
<jats:sub>ATP</jats:sub>
channels (K
<jats:sub>ir</jats:sub>
6.2 and SUR1). These phospholipids acted on the K
<jats:sub>ir</jats:sub>
6.2 subunit and shifted ATP sensitivity by several orders of magnitude. Receptor-mediated activation of phospholipase C resulted in inhibition of K
<jats:sub>ATP</jats:sub>
-mediated currents. These results represent a mechanism for control of excitability through phospholipids.
</jats:p>