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Media type:
E-Article
Title:
Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans
Contributor:
Quiring, Rebecca;
Walldorf, Uwe;
Kloter, Urs;
Gehring, Walter J.
Published:
American Association for the Advancement of Science (AAAS), 1994
Published in:
Science, 265 (1994) 5173, Seite 785-789
Language:
English
DOI:
10.1126/science.7914031
ISSN:
0036-8075;
1095-9203
Origination:
Footnote:
Description:
A Drosophila gene that contains both a paired box and a homeobox and has extensive sequence homology to the mouse Pax-6 ( Small eye ) gene was isolated and mapped to chromosome IV in a region close to the eyeless locus. Two spontaneous mutations, ey 2 and ey R , contain transposable element insertions into the cloned gene and affect gene expression, particularly in the eye primordia. This indicates that the cloned gene encodes ey . The finding that ey of Drosophila , Small eye of the mouse, and human Aniridia are encoded by homologous genes suggests that eye morphogenesis is under similar genetic control in both vertebrates and insects, in spite of the large differences in eye morphology and mode of development.