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Media type:
E-Article
Title:
Behavioral Fever in Newborn Rabbits
Contributor:
Satinoff, Evelyn;
McEwen, G. N.;
Williams, B. A.
Published:
American Association for the Advancement of Science (AAAS), 1976
Published in:
Science, 193 (1976) 4258, Seite 1139-1140
Language:
English
DOI:
10.1126/science.959829
ISSN:
0036-8075;
1095-9203
Origination:
Footnote:
Description:
Rabbit pups, 12 to 72 hours old, did not develop a fever when injected intraperitoneally with a pyrogen and maintained at an ambient temperature of 32°C for 2 hours. When placed in a thermally graded alleyway, animals injected with pyrogen selected gradient positions that represented significantly higher temperatures than controls injected with saline (40.4° in contrast to 36.4°C). Allowing the pups to remain at their selected positions for 5 minutes caused a significant increase in the rectal temperatures of the pyrogen-injected pups but not that of the controls. Thus, newborn rabbits will develop a fever by behavioral means after a single injection of an exogenous pyrogen.