• Media type: E-Article
  • Title: A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway
  • Contributor: Becker, Sidney; Thoma, Ines; Deutsch, Amrei; Gehrke, Tim; Mayer, Peter; Zipse, Hendrik; Carell, Thomas
  • Published: American Association for the Advancement of Science (AAAS), 2016
  • Published in: Science, 352 (2016) 6287, Seite 833-836
  • Language: English
  • DOI: 10.1126/science.aad2808
  • ISSN: 1095-9203; 0036-8075
  • Origination:
  • Footnote:
  • Description: Making RNA in the prebiotic world The RNA World hypothesis posits that RNA was one of the first self-replicating molecules leading to the origin of life. The nucleotide bases of RNA—A, U, C, and G—are chemically complex, and it has been unclear how the large purine bases A and G might have arisen on prebiotic Earth. Becker et al. show that the A and G bases can be synthesized easily and in high yield from prebiotically reasonable precursors, lending further support to the RNA World hypothesis. Science , this issue p. 833