Description:
<jats:title>A different form of synaptic plasticity</jats:title>
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How do synaptic or other neuronal changes support learning? This subject has been dominated by Hebb's postulate of synaptic change. Although there is strong experimental support for Hebbian plasticity in a number of preparations, alternative ideas have also been developed over the years. Bittner
<jats:italic>et al.</jats:italic>
provide in vivo, in vitro, and modeling data to support the view that non-Hebbian plasticity may underlie the formation of hippocampal place fields (see the Perspective by Krupic). Instead of multiple pairings, a single strong Ca
<jats:sup>2+</jats:sup>
plateau potential in neuronal dendrites paired with spatial inputs may be sufficient to produce place cells.
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<jats:italic>Science</jats:italic>
, this issue p.
<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="1033" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan3846">1033</jats:related-article>
; see also p.
<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6355" page="974" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao4159">974</jats:related-article>
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