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Wec, Anna Z.; Wrapp, Daniel; Herbert, Andrew S.; Maurer, Daniel P.; Haslwanter, Denise; Sakharkar, Mrunal; Jangra, Rohit K.; Dieterle, M. Eugenia; Lilov, Asparouh; Huang, Deli; Tse, Longping V.; Johnson, Nicole V.; Hsieh, Ching-Lin; Wang, Nianshuang; Nett, Juergen H.; Champney, Elizabeth; Burnina, Irina; Brown, Michael; Lin, Shu; Sinclair, Melanie; Johnson, Carl; Pudi, Sarat; Bortz, Robert; Wirchnianski, Ariel S.; [...]

Broad neutralization of SARS-related viruses by human monoclonal antibodies

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  • Media type: E-Article
  • Title: Broad neutralization of SARS-related viruses by human monoclonal antibodies
  • Contributor: Wec, Anna Z.; Wrapp, Daniel; Herbert, Andrew S.; Maurer, Daniel P.; Haslwanter, Denise; Sakharkar, Mrunal; Jangra, Rohit K.; Dieterle, M. Eugenia; Lilov, Asparouh; Huang, Deli; Tse, Longping V.; Johnson, Nicole V.; Hsieh, Ching-Lin; Wang, Nianshuang; Nett, Juergen H.; Champney, Elizabeth; Burnina, Irina; Brown, Michael; Lin, Shu; Sinclair, Melanie; Johnson, Carl; Pudi, Sarat; Bortz, Robert; Wirchnianski, Ariel S.; [...]
  • Published: American Association for the Advancement of Science (AAAS), 2020
  • Published in: Science, 369 (2020) 6504, Seite 731-736
  • Language: English
  • DOI: 10.1126/science.abc7424
  • ISSN: 0036-8075; 1095-9203
  • Origination:
  • Footnote:
  • Description: Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies. Wec et al. isolated and characterized hundreds of antibodies against the viral spike protein of SARS-CoV-2 from the memory B cells of a survivor of the 2003 outbreak caused by the related coronavirus, SARS-CoV. In both of these viruses, the spike protein facilitated viral entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor on human cells. The antibodies targeted multiple sites on the spike protein, but of nine antibodies that showed strong cross-neutralization, eight targeted the domain that binds to ACE2. These eight antibodies also neutralized a bat SARS-related virus. Illuminating the epitopes on the viral spike protein that bind cross-neutralizing antibodies could guide the design of broadly protective vaccines. Science , this issue p. 731