You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver
Contributor:
Henschke, Sinika;
Nolte, Hendrik;
Magoley, Judith;
Kleele, Tatjana;
Brandt, Claus;
Hausen, A. Christine;
Wunderlich, Claudia M.;
Bauder, Corinna A.;
Aschauer, Philipp;
Manley, Suliana;
Langer, Thomas;
Wunderlich, F. Thomas;
Brüning, Jens C.
Published:
American Association for the Advancement of Science (AAAS), 2024
Published in:
Science, 384 (2024) 6694, Seite 438-446
Language:
English
DOI:
10.1126/science.adk1005
ISSN:
0036-8075;
1095-9203
Origination:
Footnote:
Description:
Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in nutrient availability has remained unaddressed. Here, we found that sensory food perception rapidly induced mitochondrial fragmentation in the liver through protein kinase B/AKT (AKT)–dependent phosphorylation of serine 131 of the mitochondrial fission factor (MFFS131). This response was mediated by activation of hypothalamic pro-opiomelanocortin (POMC)–expressing neurons. A nonphosphorylatable MFF S131G knock-in mutation abrogated AKT-induced mitochondrial fragmentation in vitro. In vivo, MFF S131G knock-in mice displayed altered liver mitochondrial dynamics and impaired insulin-stimulated suppression of hepatic glucose production. Thus, rapid activation of a hypothalamus–liver axis can adapt mitochondrial function to anticipated changes of nutritional state in control of hepatic glucose metabolism.