Beer, Ronny;
Engelhardt, Klaus W.;
Pfausler, Bettina;
Broessner, Gregor;
Helbok, Raimund;
Lackner, Peter;
Brenneis, Christian;
Kaehler, Stefan T.;
Georgopoulos, Apostolos;
Schmutzhard, Erich
Pharmacokinetics of Intravenous Linezolid in Cerebrospinal Fluid and Plasma in Neurointensive Care Patients with Staphylococcal Ventriculitis Associated with External Ventricular Drains
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Media type:
E-Article
Title:
Pharmacokinetics of Intravenous Linezolid in Cerebrospinal Fluid and Plasma in Neurointensive Care Patients with Staphylococcal Ventriculitis Associated with External Ventricular Drains
Contributor:
Beer, Ronny;
Engelhardt, Klaus W.;
Pfausler, Bettina;
Broessner, Gregor;
Helbok, Raimund;
Lackner, Peter;
Brenneis, Christian;
Kaehler, Stefan T.;
Georgopoulos, Apostolos;
Schmutzhard, Erich
imprint:
American Society for Microbiology, 2007
Published in:Antimicrobial Agents and Chemotherapy
Language:
English
DOI:
10.1128/aac.00515-06
ISSN:
1098-6596;
0066-4804
Origination:
Footnote:
Description:
<jats:title>ABSTRACT</jats:title><jats:p>The pharmacokinetic profile of linezolid in cerebrospinal fluid (CSF) in five neurointensive care patients with staphylococcal ventriculitis was studied. The mean area under concentration-time curve (± standard deviation) was 63 ± 18.9 mg · h/liter, with a CSF-to-plasma ratio of 0.8 ± 0.3. Times above MIC in CSF were 99.8% and 57.2% for pathogens with MICs of 2 mg/liter and 4 mg/liter, respectively.</jats:p>