Schencking, Isabell;
Schäfer, Eva M.;
Scanlan, J. H. William;
Wenzel, Benjamin M.;
Emmerich, Rolf E.;
Steinmetzer, Torsten;
Diederich, Wibke E.;
Schlitzer, Martin;
Hartmann, Roland K.
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Media type:
E-Article
Title:
RNase P Inhibitors Identified as Aggregators
Contributor:
Schencking, Isabell;
Schäfer, Eva M.;
Scanlan, J. H. William;
Wenzel, Benjamin M.;
Emmerich, Rolf E.;
Steinmetzer, Torsten;
Diederich, Wibke E.;
Schlitzer, Martin;
Hartmann, Roland K.
imprint:
American Society for Microbiology, 2021
Published in:Antimicrobial Agents and Chemotherapy
Description:
<jats:p>RNase P is an essential enzyme responsible for tRNA 5′-end maturation. In most bacteria, the enzyme is a ribonucleoprotein consisting of a catalytic RNA subunit and a small protein cofactor termed RnpA. Several studies have reported small-molecule inhibitors directed against bacterial RNase P that were identified by high-throughput screenings.</jats:p>