Published:
American Society for Microbiology, 2018
Published in:
Antimicrobial Agents and Chemotherapy, 62 (2018) 7
Language:
English
DOI:
10.1128/aac.00385-18
ISSN:
0066-4804;
1098-6596
Origination:
Footnote:
Description:
ABSTRACT Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage endolysin HY-133 has proved to be an active agent against S. aureus . Here, the in vitro activity of HY-133 was studied against a large collection of genetically diverse LA-MRSA isolates revealing its high activity against mecA -, mecB -, and mecC -positive LA-MRSA.